Different definitions of sarcopenia and mortality in cancer: A meta-analysis

• DOI: 10.1016/j.afos.2021.02.005
• Publication Date: 2021-03-20T07:52:22Z
• Authors: Hang-Long Li; Philip Chun-Ming Au; Grace Koon-Yee Lee; Gloria Hoi-Yee Li; Marcus Chan; Bernard Man-Yung ...; Ian Chi-Kei Wong; Victor Ho-Fun Lee; James Mok; Benjamin Hon-Kei Yip; Kenneth King-Yip ...; Chih-Hsing Wu; Ching-Lung Cheung
• Keywords: Cut-off

Sarcopenia has been an emerging theme in clinical oncology. Various definitions of sarcopenia have proposed, but their prognostic performance yet to be evaluated and compared. The aim this meta-analysis is comprehensively evaluate the different cutoff cancer mortality prognostication. This a meta-analysis. Cohort studies on lean mass published before December 20, 2017 were obtained by systematic search PubMed, Cochrane Library, Embase. Inclusion criteria cohort reporting binary categorized according clearly defined cutoffs, with all-cause as study outcome. Studies stratified cutoff(s) used defining low mass. cutoff-specific hazard ratios (HRs) 95% confidence intervals (CIs) pooled random-effects model Altogether 81 that studied included. HRs using 3 most were: 1.74 (95% CI, 1.46–2.07) definition proposed International Consensus Cancer Cachexia, 1.45 1.21–1.75) Martin, 1.58 1.35–1.84) Prado. associations between other all statistically significant, despite estimates observed. association increased was consistent across definitions; provides further evidence poorer survival patients sarcopenia. However, evaluating each are warranted.