Distal versus conventional radial access for coronary angiography and intervention: Design and rationale of DISCO RADIAL study

• DOI: 10.1016/j.ahj.2021.10.180
• Publication Date: 2021-10-18T17:32:21Z
• Authors: Adel Aminian; Gregory A. Sgueglia; Marcus Wiemer; Gabriele Luigi Ga...; Joelle Kefer; Zoltan Ruzsa; Maarten A.H. van ...; Bert Vandeloo; Claudiu Ungureanu; Sasko Kedev; Juan F Iglesias; Gregor Leibundgut; Karim Ratib; Ivo Bernat; Irene Barriocanal; Vladimir Borovicanin; Shigeru Saito
• Keywords: Multicenter trial

Transradial access (TRA) has become the default method for coronary diagnostic and interventional procedures. As compared to transfemoral access, TRA been shown be safer, cost-effective more patient-friendly. Radial artery occlusion (RAO) represents most frequent complication of TRA, precludes future procedures through radial artery, use as a conduit bypass grafting or arteriovenous fistula patients on hemodialysis. Recently, distal (DRA) emerged promising alternative yielding potential minimizing risk RAO. However, an international multicenter randomized comparison between DRA, conventional with respect rate RAO is still lacking. DISCO RADIAL prospective, multicenter, open-label, randomized, controlled, superiority trial. A total 1300 eligible will randomly allocated undergo angiography and/or percutaneous intervention (PCI) DRA using 6 Fr Glidesheath Slender sheath introducer. Extended experience both required operators’ eligibility optimal evidence-based best practice reduce systematically implemented by protocol. The primary endpoint incidence forearm assessed vascular ultrasound at discharge. Several important secondary endpoints also assessed, including access-site cross-over, hemostasis time, related complications. trial provide first large-scale evidence comparing in scheduled PCI