Circulating angiogenic factors in gestational proteinuria without hypertension

• DOI: 10.1016/j.ajog.2008.10.033
• Publication Date: 2009-01-27T09:31:10Z
• Authors: Alexander M. Holston; Cong Qian; Kai F. Yu; Franklin H. Epstein; S. Ananth Karumanchi; Richard J. Levine
• Keywords: Vascular Endothelial Growth Factor Receptor-1; Endoglin; Receptors, Cell Surface; Pregnancy Proteins; Pregnancy Complications; Proteinuria; Young Adult; 03 medical and health sciences; 0302 clinical medicine; Antigens, CD; Pregnancy; Case-Control Studies; Humans; Angiogenesis Inducing Agents; Female; Placenta Growth Factor

Our goal was to determine whether obstetric outcomes and serum angiogenic factors are altered in women with gestational proteinuria without hypertension.We performed a nested case-control study of 108 women with gestational proteinuria and compared them with 1564 randomly selected women with normotension without proteinuria during pregnancy (control subjects) and with 319 women who experienced preeclampsia.Women with gestational proteinuria had greater body-mass index and higher blood pressure at study enrollment. Adverse obstetric outcomes were infrequent. Levels of free placental growth factor were lower than control levels beginning early in gestation. Compared with gestational-age matched control subjects, free placental growth factor was reduced beginning 6-8 weeks before proteinuria. Although soluble fms-like tyrosine kinase 1 and soluble endoglin concentrations were elevated 1-2 weeks before proteinuria, these elevations were modest and transient. After the onset of proteinuria, angiogenic factor levels generally did not differ significantly from control levels.Gestational proteinuria in healthy nulliparous women appears to be a mild variant of preeclampsia.