Long Interspersed Element-1 Protein Expression Is a Hallmark of Many Human Cancers

• DOI: 10.1016/j.ajpath.2014.01.007
• Publication Date: 2014-03-09T00:15:37Z
• Authors: Nemanja Rodić; Reema Sharma; Rajni Sharma; John Zampella; Lixin Dai; Martin S. Taylor; Ralph H. Hruban; Christine A. Iaco...; Anirban Maitra; Michael S. Torbenson; Michael Goggins; Ie-Ming Shih; Amy S. Duffield; Elizabeth A. Mont...; Edward Gabrielson; George J. Netto; Tamara L. Lotan; Angelo M. De Marzo; William Westra; Zev A. Binder; Brent A. Orr; Gary L. Gallia; Charles G. Eberhart; Jef D. Boeke; Chris R. Harris; Kathleen H. Burns
• Keywords: 0303 health sciences; 03 medical and health sciences; Cell Line, Tumor; Neoplasms; Deoxyribonuclease I; Humans; Tumor Suppressor Protein p53; Pathology and Forensic Medicine; 3. Good health

Cancers comprise a heterogeneous group of human diseases. Unifying characteristics include unchecked abilities tumor cells to proliferate and spread anatomically, the presence clonal advantageous genetic changes. However, universal highly specific markers are unknown. Herein, we report widespread long interspersed element-1 (LINE-1) repeat expression in cancers. We show that nearly half all cancers immunoreactive for LINE-1-encoded protein. LINE-1 protein is common feature many types high-grade malignant cancers, rarely detected early stages tumorigenesis, absent from normal somatic tissues. Studies have shown contributes changes with insertions seen selected particularly colon cancer. sought correlate this observation protein, open reading frame 1 found surprisingly broad, yet tumor-specific, antigen.