Recent advances in zwitterionic nanoscale drug delivery systems to overcome biological barriers

• DOI: 10.1016/j.ajps.2023.100883
• Publication Date: 2023-12-29T17:25:54Z
• Authors: Xumei Ouyang; Yu Liu; Ke Zheng; Zhiqing Pang; Shaojun Peng
• Keywords: PEGylation

Nanoscale drug delivery systems (nDDS) have been employed widely in enhancing the therapeutic efficacy of drugs against diseases with reduced side effects. Although several nDDS successfully approved for clinical use up to now, biological barriers between administration site and target hinder wider adoption disease treatment. Polyethylene glycol (PEG)-modification (or PEGylation) has regarded as gold standard stabilising complex environment. However, accelerated blood clearance (ABC) PEGylated after repeated injections becomes great challenges their applications. Zwitterionic polymer, a novel family anti-fouling materials, evolved an alternative PEG due super-hydrophilicity biocompatibility. could avoid generation ABC phenomenon exhibit longer circulation time than analogues. More impressively, zwitterionic recently shown overcome multiple such nonspecific organ distribution, pressure gradients, impermeable cell membranes lysosomal degradation without need any chemical modifications. The realization overcoming by may simplify current overly design nDDS, which facilitate better translation. Herein, we summarise recent progress at various analyse underlying mechanisms. Finally, prospects are introduced guide rational