Effect of oral immunotherapy in children with milk allergy: The ORIMA study

• DOI: 10.1016/j.alit.2020.09.011
• Publication Date: 2020-11-25T14:17:27Z
• Authors: Mayu Maeda; Takanori Imai; Ryoko Ishikawa; Toshinori Nakamura; Taro Kamiya; Ayako Kimura; Satoshi Fujita; Kenichi Akashi; Hitomi Tada; Hideaki Morita; Kenji Matsumoto; Toshio Katsunuma
• Keywords: Oral immunotherapy; Milk allergy; Oral food challenge; Cow's milk allergy

This study was aimed at evaluating the efficacy and safety of oral immunotherapy (OIT) in children with severe cow's milk allergy. The subjects comprised 28 (aged 3–12 years) allergic symptoms that were induced by ≤ 10 mL an food challenge test (OFC). randomly allocated to treatment group (n = 14) control 14); former received rush for 2 weeks, followed a gradual increase volume 100 1 year, latter completely eliminated year. Both groups underwent OFC after had significantly higher rates negative [7/14 (50%) vs. 0/14 (0%), p < 0.01] compared group. milk-specific IgE level decreased (p 0.01) but not 0.63). During period, adrenaline required 6/14 patients (43%) (0%) Long follow-up data available 2-year point 8 7 (87.5%) these continued ingest (>100 mL). effect 50%, incidence adverse events low. Further studies focusing on is necessary standardize OIT