Short- and long-term outcomes after Kasai operation for type III biliary atresia: Twenty years of experience in a single tertiary Egyptian center-A retrospective cohort study

• DOI: 10.1016/j.amsu.2021.01.052
• Publication Date: 2021-01-23T08:36:38Z
• Authors: Emad Hamdy Gad; Yasmin Kamel; Tahany Abdel-Hame...; Mohammed Abdel-Ha...; Ahmed Nabil Sallam
• Keywords: Single Center

Kasai portoenterostomy(KPE) is the treatment of choice for fatal devastating infantile type III biliary atresia (BA). The study aimed to analyze short-and long-term outcomes after this procedure and their predictors in a tertiary center. Methods: We retrospectively analyzed 410 infants who underwent KPE BA period from February 2000 December 2019. overall male/female ratio was 186/224. Results: early (<6months) complications involved 187(45.6%) our with higher incidence cholangitis that affected 108(26.3%) them. jaundice clearance at 6th post-operative month reached 138(33.7%) them had an independent correlation mild portal tracts ductal and/or ductular proliferation, using postoperative steroids therapy, absence cholangitis. infant mortality 70(17.1%) patients mostly sepsis. On other hand, late (>6months) mortalities 256(62.4%) 240(58.5%) respectively; moreover, liver failure sepsis were most frequent causes non-transplanted transplanted cases respectively. Lastly, (20-year) native survival (NLS) 91(22.2%) age operation < 90 days, preoperative mean serum alb, tract fibrosis grades F0 F1, intraoperative bleeding, cholangitis, occurrence hypertension (PHN). Conclusions: Sepsis direct effect on patient BA; >90 grades, PHN, persistence negative insult outcome. So, it crucial modulate these factors better