Systemic lidocaine administration influences NF-kβ gene expression, NF-kβ and TNF- α protein levels on BALB/c mice with musculoskeletal injury

• DOI: 10.1016/j.amsu.2021.102660
• Publication Date: 2021-08-05T10:57:02Z
• Authors: Resiana Karnina; Syafri Kamsul Arif; Mochammad Hatta; Agussalim Bukhari; Rosdiana Natzir; Hisbullah; Ilhamjaya Patellongi; Cahyono Kaelan
• Keywords: 0301 basic medicine; 03 medical and health sciences; Experimental Research; 3. Good health

The immune system can produce various inflammatory mediators to protect the body from stress and surgical trauma. However, this excessive response will interfere with body's system, causing systemic syndrome multi-organ failure if allowed continue. Lidocaine as an anti-inflammatory is used treat pain arising disease process ventricular arrhythmias. This study aims prove efficacy of lidocaine injection drug in BALB/c mice sterile musculoskeletal injuries.