Combined spinal and general anesthesia attenuate tumor promoting effects of surgery. An experimental animal study

• DOI: 10.1016/j.amsu.2022.103398
• Publication Date: 2022-02-24T19:10:30Z
• Authors: Gustavo N.C. Inoue; Ruan Pimenta; Juliana A. Camargo; Nayara I. Viana; Vanessa R. Guimarães; Miguel Srougi; William C. Nahas; Katia R.M. Leite; Sabrina T. Reis
• Keywords: Spinal Surgery; Animal model; Animal studies

Radical prostatectomy, a standard management approach for localized Prostate Cancer (PC), may cause stress response associated with immune modulating effects. Regional anesthesia was hypothesized to reduce the effects of surgery by minimizing neuroendocrine surgical response, thus mitigating tumor cells dissemination. Our primary objective investigate whether use spinal blocks attenuates PC dissemination on an animal model. We also assessed number circulating NK and amount inflammatory anti-inflammatory cytokines. A subcutaneous model, PC-3M cell line transfected luciferase-producing gene (PC-3M-luc-C6) used. After proper establishment before tumors became metastatic, animals were submitted excision surgeries under general or combined (general spinal) anesthesia. control group only anesthetized The model PC-3M-luc-C6 effective in causing distant metastasis after 35 days. increased that underwent alone compared Interleukin 6 levels different all groups, increase group. results suggest combination attenuate suppression innate immunity it might be related reduction surgery. Animal Ethics Committee 1332/2019.