Maternal stevioside supplementation improves intestinal immune function of chicken offspring potentially via modulating gut microbiota and down-regulating the promoter methylation level of suppressor of cytokine signaling 1 (SOCS1)

• DOI: 10.1016/j.aninu.2022.06.002
• Publication Date: 2022-06-15T03:07:45Z
• Authors: Jingle Jiang; Lina Qi; Quanwei Wei; Fangxiong Shi
• Keywords: Litter

The intestinal immune function of chickens is limited during the early growing stage. Maternal nutritional intervention has been suggested to affect innate immunity offspring. present study aimed investigate effects maternal stevioside supplementation on chicken A total 120 Jinmao yellow-feathered breeder hens were fed a basal diet or supplemented with 250 mg/kg for 5 weeks. During last week, 200 breeding eggs from each group collected incubation. After hatching, 80 male offspring (40 group) randomly selected and same 28 d. In addition, 90 well-shaped fertile non-treated incubated in ovo injection experiment. Steviol dissolved 20% glycerol was injected at 7 d results showed that could improve embryonic development, jejunal integrity proliferation crypt (P < 0.05). also increase transcription levels cytokines endotoxin tolerance-related factors jejunum At age, following exhibited higher secretory immunoglobulin serum interferons abundance Lactobacillales induced by positively correlated immune-related steviol did not alter either development hatching > Furthermore, induce hypo-methylation promoter region suppressor cytokine signaling 1 (SOCS1). conclusion, potentially via modulating gut microbiota down-regulating methylation level SOCS1.