P-9 AUTOIMMUNE LIVER DISEASES IN LATIN AMERICA: A WEB-BASED SURVEY

• DOI: 10.1016/j.aohep.2023.101196
• Publication Date: 2024-02-26T20:05:30Z
• Authors: Claudia Alves; Guilherme Grossi ...; Debora Raquel B; Eduardo Luiz Rachid; Daniela Chiodi; Javier Brahm; Carlos Bernardo S...; Manuel Gatica; Carmen Pollio; Juan Diego De La ...; Ezequiel Ridruejo; Marcos Girala; Zuly Plácido; Martin Padilla; Gabriel Sebastian...; Gustavo Bresky; Julissa Lombardo; Diana Torres; Harlim Rodriguez; Melisa Dirchwolf; Juanita Pérez; Lesvia Arrunategui; Nicolás Lama; Fátima Higuera; Cristiane Villela; Mario Reis; Walter Barriga; Gonzalo Araneda; Gisela Gualano; Pedro Andrés Montes; Vivian Rotman; Rodolfo Antonio O...; Patricia Guerra; Juan Antonio Otegui; Alejandro Ferrada; Maria Laura Garrido; Mauricio Carrasco; Alma Kuljacha; Marco Sánchez; Graciela Castro; Viridiana López; Ana Alicia Martínez; Ruth González; Gustavo Henrique; Eira Cerda; Alejandro Soza; Mirta Peralta; Diego Arufe; Fernando Gómez; Gustavo Calle; Carlos García; Scherezada Mejia; Santiago Rodríguez; Nicolas Jaquin Fe...; María Noel García; Mario Guimaraes
• Keywords: Autoimmune Hepatitis

Autoimmune liver diseases (AILD), including autoimmune hepatitis (AIH), primary biliary cholangitis (PBC), and sclerosing (PSC), are chronic immune-mediated conditions. This study aimed to assess the reality of AILD in Latin America (LA). A web-based survey consisting 35 questions on was distributed hepatologists affiliated with ALEH through social media. total 65 participated survey. The most treated region AIH. Widely available antibodies for diagnosis included anti-mitochondrial (100%), anti-smooth muscle (98.5%), anti-nuclear (95.4%), while access anti-gp210/sp100 limited (<55%). Although 97% had biopsy, only 72.3% were assisted by pathologists. Elastography endoscopic retrograde cholangiopancreatography 90.8% 98.5%, respectively. Ursodeoxycholic acid (UDCA) medication PBC followed fibrates (bezafibrate: 56.3%, fenofibrate: 71.9%). There considerable heterogeneity selecting criteria evaluate response UDCA, 39.3% favoring Paris II criteria. Cholestyramine/antihistamines commonly recommended treating pruritus, used 47.7%. For PSC, 86.2% indicated use UDCA. Azathioprine main immunosuppressor employed AIH treatment, although indications treatment controversial. Most physicians patients signs active disease, regardless enzyme IgG levels. Prednisone alone decompensated cirrhosis (70.7%). Remission mostly defined normalization enzymes minimal/absent inflammation histology (47.7%), 60% respondents performing biopsies histological remission. While 62.5% participants attempted withdraw 78% refrained from discontinuing presence anti-SLA. provides valuable insights into current management LA, highlighting areas that warrant further investigation.