P- 40 PENTOXIFYLLINE USE IN PATIENTS WITH ALCOHOL-ASSOCIATED HEPATITIS ADMITTED WITH ACUTE KIDNEY INJURY COULD DECREASE SURVIVAL: A GLOBAL STUDY

• DOI: 10.1016/j.aohep.2023.101227
• Publication Date: 2024-02-26T20:06:03Z
• Authors: Francisco Idalsoaga; Luis Antonio Diaz; Oscar Corsi; Gustavo Ayares; Jorge Arnold; Winston Dunn; Yanming Li; Ashwani Singal; Doug Simonetto; María Ayala-Valverde; Carolina A Ramirez; Dalia Morales-Arraez; Wei Zhang; Steve Qian; Joseph Ahn; Seth Buryska; Heer Mehta; Muhammad Waleed; Horia Stefanescu; Adelina Horhat; Andreea Bumbu; Bashar Agrawal; Rohit Agrawal; Joaquín Cabezas; Berta Cuyàs; Maria Poca; German Soriano Pa...; Shiv K Sarin; Rakhi Maiwall; Prasun K Jalal; María Fátima Higu...; Anand Kulkarni; Nagaraja Rao; Patricia Guerra S...; Lubomir Skladaný; Natália Bystrianska; Veronica Prado; Ana Clemente-Sanchez; Diego Rincón; Tehseen Haider; Kristina R Chacko; Gustavo A Romero; Florencia Pollarsky; Juan Carlos Restrepo; Luis G Toro; Pamela Yaquich; Manuel Mendizabal; Maria Laura Garrido; Sebastian Marciano; Melisa Dirchwolf; Victor Vargas; Cesar Jimenez; Guadalupe García-...; Guillermo Ortiz; Juan G Abraldes; Patrick Kamath; Vijay Shah; Ramon Bataller; Juan Pablo Arab
• Keywords: Pentoxifylline

Alcohol-associated hepatitis (AH) is a severe entity with mortality of up to 30–50% at 1 month. Pentoxifylline combined steroids has not demonstrated benefits in AH. Some studies have suggested that pentoxifylline may be beneficial the subgroup patients acute kidney injury (AKI) and However, there no solid evidence its benefit this setting. This study aimed determine use AH AKI. Global retrospective cohort study, including AKI admission (2009–2019). We used competing-risk models liver transplantation as competing risk assess potential effect pentoxifylline. included 655 (30 centers from 10 countries). Median age was 48±11.6 years, 26.2% were females, 52.5% Caucasian. Around 68.7% had prior history cirrhosis, 6.6% underwent transplantation. The MELD score on 34 [15–74]. 43.2% corticosteroids, while only 6.9% during hospitalization. In univariate analysis, variables independently associated female sex (sHR 0.740; 95%IC:0.577–0.948; p=0.018), 1.034; 95%IC: 1.020–1048; p<0.001), 3.0 1.034,95%IC:1.018–1.049, Maddrey's discriminant function 1.005, 95%IC:1.003–1.008, serum albumin 0.756; 95%IC:0.642–0.890; p=0.001), bilirubin 1.011; 95%IC:1.003–1.019, p=0.006), creatinine 1.083; 95%IC:1.028–1.140, p=0.002) 1.531, 95%IC:1.107–2.119; p=0.010)(Table). multivariate-adjusted model, increased 1.620, 95%IC:1.190–2.204; p=0.002). terms could decrease survival