O-17 NUTRICIONAL AND PHYSICAL THERAPHY IMPROVES LIVER FRAILTY INDEX IN LISTED PATIENTS WITH CIRRHOSIS: RANDOMIZED CONTROLLED TRIAL. INTERIM ANALYSIS

• DOI: 10.1016/j.aohep.2023.101267
• Publication Date: 2024-02-26T20:06:53Z
• Authors: Diego Reyes; Carlos Benitez; Anny Galvez; Catalina Grandy; Nicolás Lavados; Isidora Cerda; Nicole Kim; Lucas Lacalle; Sebastián Rosales; Eduardo Fuentez-L...; Francisco Cerda; Silvana Valdés; Valeria Cuzmar; Soledad Contreras; Teresita Risopatrón; Roberto Candia
• Keywords: Interim; Interim analysis

Frailty is independently associated with a lower survival in cirrhotic patients. Liver Index (LFI) determine frailty listed patients predicting survival. This study aimed to evaluate the effect of physical and nutritional therapy (intervention group) over LFI compared counseling (control group). Patients were recruited randomized an intervention group or control group. followed for 12 weeks evaluations every 4 weeks. We at different time points between both groups during follow-up. 46 recruited, 27 them 19 50% women most common etiologies metabolic fatty liver disease (37%) alcoholic (19.6%), primary biliary cholangitis (6.52%), autoimmune hepatitis (6.52%) C virus (2.17%). The median (IQR) age was 60 years (53-63 years), MELD-Na 17 (15-21), creatinine 0.75 mg/dl (0.6-0.8) albumin 3.1 g/dl (2.9-3.1), INR 1.54 (1.4-1.75) bilirubin 2.6 (1.4-1.7). Child-Pugh scores A/B/C 13%/58.7%/28.3% respectively. No differences baseline characteristics found groups. Notably, there significant improvement (median; IQR) (Figure 1) after 8 3.74 (3.37-3.97) -0.86 vs. 4.15 (3.94-4.23) -0.02, p=0.007) 3.73 (3.31-4.11) -0.87 4.14 (4.06-4.50) -0.03, p=0.023). In this interim analysis improves LFI. first controlled trial positive results cirrhosis.