Outcomes and risk factors for mortality in clostridioides difficile infection in patients with NAFLD and NASH

• DOI: 10.1016/j.aohep.2024.101510
• Publication Date: 2024-05-05T05:23:06Z
• Authors: Ankoor H. Patel; Gaurav N. Pathak; Alexander Chen; Patricia Greenberg; Natale Mazzaferro; Anish Patel; Naveen Mallangada; Carlos D. Minacap...; Kaitlyn Catalano; Hansel Suthar; Vinod K. Rustgi
• Keywords: Liver disease

Non-alcoholic fatty liver disease (NAFLD) is the most common worldwide and can progress to non-alcoholic steatohepatitis (NASH) and, ultimately, cirrhosis. Clostridioides difficile nosocomial cause of diarrhea associated with worse clinical outcomes in other diseases, including cirrhosis, but has not been extensively evaluated concomitant NAFLD/NASH. We conducted a retrospective cohort study using National Inpatient Sample database from 2015 2017. Patients diagnosis CDI, NAFLD, NASH were identified International Classification Diseases (Tenth Revision) codes. The our include length stay, hospitalization cost, mortality, predictors mortality. CDI had higher degree comorbidity burden prevalence peptic ulcer disease, congestive heart failure, diabetes mellitus, significantly mortality rate compared only (mortality, 7.11% vs 6.36%; P = 0.042). at increased risk for liver-related complications, acute kidney injury, septic shock (P < 0.001) patients only. Older age, intestinal pneumonia, sepsis shock, failure conferred an among cohort. progression following infection