Is the use of hemostatic matrix (Floseal) and alkylene oxide copolymer (Ostene) safe in spinal laminectomies? Peridural fibrosis assessment

• DOI: 10.1016/j.aott.2017.02.006
• Publication Date: 2017-02-28T03:00:20Z
• Authors: Oktay Gurcan; Ahmet Gurhan Gurcay; Atilla Kazanci; Evrim Onder; Salim Senturk; Murad Bavbek
• Keywords: Spinal column

Failed Back Syndrome (FBS) is unacceptable relief of pain or recurrence symptoms in patients after spinal surgery, such as laminectomy. One possible cause FBS peridural fibrosis (PF). PF the overproduction scar tissue adjacent to dura mater. Bleeding can Ostene an alkylene oxide copolymer material used stop bleeding from bony surfaces. Floseal a gelatin thrombin matrix sealant assist fibrin formation and promote coagulation.Total 32 female Sprague-Dawley rats were evenly allotted 4 experimental groups: laminectomy only, + (Baxter International, Inc., Deerfield, IL, USA), Adcon-L (aap Implantate AG, Berlin, Germany). After performing total laminectomy, agents placed over Spinal column test subjects was harvested 6 weeks Histopathological examination samples based on Masson's trichrome hematoxylin eosin staining. observed groups graded using system previously described by He et al. Statistically significant p value defined < 0.005.Present study revealed that Adcon-L, Ostene, had reduced compared with only group (p = 0.001). Comparison yielded no difference.Reoperation result has greater risk often poor outcome; surgeons must take precautions avoid FBS, careful selection appropriate patient operation technique. may be applied left field safely during reduce occurrence procedure.