Two-dimensional speckle tracking echocardiography in evaluating radiation-induced heart damage

• DOI: 10.1016/j.apjon.2021.12.008
• Publication Date: 2021-12-25T01:34:04Z
• Authors: Tingcui Li; Hongqing Zhuang; Yuxia Wang; Jun Li; Dan Zhu; Ming Cui
• Keywords: Mace

Radiation-induced heart damage (RIHD) in malignant tumor patients with thoracic radiotherapy has been well documented. However, there is no study on the cardiac toxicity of stereotactic body (SBRT) based two-dimensional speckle tracking echocardiography (2D STE).In a prospective cohort trial, 48 (including lung cancer, pulmonary metastases and other tumor) were assigned to receive SBRT. Circulating biomarkers, electrocardiogram (ECG), echocardiography, 2D STE performed prior within two months after radiotherapy. The primary outcome trial was decrease global longitudinal strain (GLS) ≥ 10%. secondary outcomes major adverse cardiovascular events (MACE). Analysis conducted using paired sample t-test, Wilcoxon signed rank test Chi square test.The morbidity RIHD 44% 2 SBRT patients. Compared pre-RT, significant GLS observed post-RT (-17.98 ​± ​3.54% vs. -16.92 ​3.41%; P ​= ​0.008), without any change left ventricular ejection fraction (LVEF) (68.54 ​6.06 69.63 ​4.45; ​0.234), mass (LVM) (P ​0.342), ECG parameters, creatine kinase ​0.074), troponin T ​0.829) or N-terminal pro-B-type natriuretic peptide ​0.453) at during period. There evidence that correlated age ​1.000), mean dose ​0.602), BED EQD2/2 ​0.615), V5 ​0.506), V10 ​0.578), V20 ​0.670) V30 ​0.741). Subgroup analysis showed, still decline (-18.30 ​3.79% -17.11 ​3.58%; ​0.018) anthracycline treatment. And (-19.14 ​2.42% -16.85 ​2.46%; ​0.004) more significantly treatment group. MACE found one patient over period SBRT.By subclinical dysfunction be evident early SBRT, despite unchanged conventional indices such as LVEF, parameters circulating biomarkers. existed effect removed.ClinicalTrials.gov, registration number: NCT04443400.