Repurposing disulfiram with CuET nanocrystals: Enhancing anti-pyroptotic effect through NLRP3 inflammasome inhibition for treating inflammatory bowel diseases

• DOI: 10.1016/j.apsb.2024.03.003
• Publication Date: 2024-03-15T08:49:01Z
• Authors: Xueming Xu; Yuanfeng Han; Jiali Deng; Shengfeng Wang; Shijie Zhuo; Kai Zhao; Wenhu Zhou
• Keywords: Druggability; Pyroptosis; Disulfiram; Drug repositioning; Repurposing

Drug repurposing offers a valuable strategy for identifying new therapeutic applications existing drugs. Recently, disulfiram (DSF), drug primarily used alcohol addiction treatment, has emerged as potential treatment inflammatory diseases by inhibiting pyroptosis, form of programmed cell death. The activity DSF can be further enhanced the presence Cu