Heme oxygenase 1-mediated ferroptosis in Kupffer cells initiates liver injury during heat stroke

• DOI: 10.1016/j.apsb.2024.05.007
• Publication Date: 2024-05-13T15:47:10Z
• Authors: Ru Li; Riqing Wei; Chenxin Liu; Keying Zhang; Sixiao He; Zhifeng Liu; Junhao Huang; Youyong Tang; Qiyuan An; Ligen Lin; Lishe Gan; Liying Zhao; Xiaoming Zou; Fudi Wang; Yuan Ping; Qiang Ma
• Keywords: Stroke; Kupffer cell; Cell damage

With the escalating prevalence of global heat waves, stroke has become a prominent health concern, leading to substantial liver damage. Unlike other forms injury, stroke-induced damage is characterized by cytotoxicity and heightened inflammation, directly contributing elevated mortality rates. While clinical assessments have identified bilirubin levels as indicative Kupffer cell dysfunction, their specific correlation with injury remains unclear. Our hypothesis proposes involvement ferroptosis during stroke, initiating IL-1