Bioinspired plasmonic nanoflower-decorated microneedle for label-free intradermal sensing

• DOI: 10.1016/j.apsusc.2021.149411
• Publication Date: 2021-03-05T21:08:50Z
• Authors: Vo Thi Nhat Linh; Sang-Gu Yim; ChaeWon Mun; Jun-Yeong Yang; Seunghun Lee; Yeon Woo Yoo; Dong Kyung Sung; Yong-Ill Lee; Dong-Ho Kim; Sung-Gyu Park; Seung Yun Yang; Ho Sang Jung
• Keywords: Nanoflower

A bioinspired nanoflower structure was fabricated on microneedle (MN) to utilize as a surface-enhanced Raman scattering (SERS) sensor for intradermal sensing applications. On the surface of poly (lactic-co-glycolic acid) (PLGA) MN, polydopamine (PD) coated an interlayer, and hydroxyapatite (HA) which is flower-like-structured bone mineral crystalized via bio-mineralization in simulated body fluid (SBF). Au deposited HA-coated (HA-MN) generate SERS effect. Scanning electron microscopy (SEM) images showed structures Au-coated HA-MN (Au-nanoflower microneedle; NFMN) dense nanoislands (AuILs) formed each lath-like petal surface. After characterization NFMN-SERS sensor, electromagnetic field distribution investigated by finite-difference time-domain (FDTD) simulation identify origin methylene blue (MB) detected down concentration 50 nM with uniform tip-to-tip signal intensity. Furthermore, feasibility using skin phantom model. The MB molecule contained dermis region 1 after simple insertion withdrawal. developed expected be applied various sensing, especially chemical biomarkers interstitial fluids skin.