The growth-promoting and lipid-lowering effects of berberine are associated with the regulation of intestinal bacteria and bile acid profiles in yellow catfish (Pelteobagrus fulvidraco)

• DOI: 10.1016/j.aqrep.2023.101848
• Publication Date: 2023-11-18T13:01:39Z
• Authors: Lei Wang; Chang Gao; Leqi Yang; Chenyang Wang; Bin Wang; Heng Wang; Yilin Shu; Yunzhi Yan
• Keywords: 0301 basic medicine; Yellow catfish; 03 medical and health sciences; Berberine; FXR; Aquaculture. Fisheries. Angling; SH1-691; Lipid accumulation; Bile acids

Berberine has growth-promoting and lipid-lowering effects potentially through the regulation of intestinal microbiota bile acid profiles. This experiment aimed to investigate effect dietary berberine on microbiota-bile acid-farnesoid X receptor (FXR) axis in yellow catfish (Pelteobagrus fulvidraco). Fish (initial weight: 1.32 ± 0.26 g) were fed a control diet or supplemented with 100 mg/kg (BBR100) 400 (BBR400) for 60 days. The BBR400 group showed significant improvements growth performance, hepatic antioxidant enzyme activities, lysozyme activity, cholic acid, ethylchenodeoxycholic hydroguinone carboxylic contents, along significantly lower immunoglobulin M, complement 3, 4, serum total cholesterol (TCH), triglyceride (TG) compared (P < 0.05). In addition, both levels resulted reductions viscerosomatic index, hepatosomatic condition factor, TCH, TG, malondialdehyde as well alanine aminotransferase activity low-density lipoprotein content. supplementation also upregulated expression fxr fibroblast factor 19, fxr, short heterodimeric partners, lipolysis genes, while inhibiting lipogenesis genes. Furthermore, treatment improved histological parameters increased abundance probiotic bacteria such Ruegeria Bifidobacterium, reducing potential pathogenic Pseudomonas, Psychrobacter, Vibrio, Pseudonocardia. Overall, this study suggests that berberine's might be attributed its modulation microbiota, profile, FXR signaling.