Lipoprotein(a) distribution and its association with carotid arteriopathy in the Chinese population

• DOI: 10.1016/j.atherosclerosis.2023.03.007
• Publication Date: 2023-03-15T09:56:33Z
• Authors: Lijin Lin; Ke-Qiong Deng; Ze Chen; Fang Lei; Juan-Juan Qin; Xuewei Huang; Tao Sun; Xingyuan Zhang; Yingying Hu; Peng Zhang; Yan-Xiao Ji; Xiao-Jing Zhang; Zhi-Gang She; Zhibing Lu; Jingjing Cai; Hongliang Li
• Keywords: Lipoprotein(a)

Background and aimsThe distribution of lipoprotein(a) [Lp(a)] has not been well-studied in a large population China. The relationship between Lp(a) carotid atherosclerosis remains undefined. In this study, we aimed to investigate the levels assess their association with arteriopathy China.MethodsIn cross-sectional 411,634 adults measurements from 22 health check-up centers were used Among participants data, ultrasound was performed routinely at seven covering 75,305 subjects. Carotid intima-media thickness (cIMT) plaque as surrogate biomarkers arteriopathy. multivariate logistic regression model applied evaluate increased arteriopathy.ResultsThe concentrations right-skewed, median concentration 10.60 mg/dL. proportions ≥30 mg/dL ≥50 16.75% 7.10%, respectively. level higher females individuals northern China, age. Spearman's analysis revealed weak correlations continuous variable other lipid profiles. multiple showed that had an risk cIMT ≥1.0 mm (OR = 1.138, 95% CI, 1.071–1.208) 1.296, 1.219–1.377) compared those <50 mg/dL.ConclusionsThis is first study Our findings positive elevated (≥50 mg/dL) prevalence atherosclerosis, which implies cardiovascular disease future.