Atherogenic index predicts all-cause and cardiovascular mortality in incident peritoneal dialysis patients

• DOI: 10.1016/j.atherosclerosis.2023.117389
• Publication Date: 2023-11-18T04:42:28Z
• Authors: Jihong Deng; Xingming Tang; Ruiying Tang; Jiexin Chen; Huankai Guo; Qian Zhou; Xiaojiang Zhan; Haibo Long; Fenfen Peng; Xiaoyang Wang; Yueqiang Wen; Xiaoran Feng; Ning Su; Na Tian; Xianfeng Wu; Qingdong Xu
• Keywords: Quartile; Interquartile range

Atherosclerosis, the main cause of cardiovascular disease (CVD), is prevalent in patients undergoing peritoneal dialysis (PD). Atherogenic index (AI) a strong predictor atherosclerosis. However, its prognostic value CVD outcomes and all-cause mortality among PD remains uncertain. Therefore, we aimed to evaluate association between AI patients.Calculated based on lipid profiles obtained through standard laboratory procedures, was evaluated 2682 who underwent therapy January 2006 December 2017 were followed up until 2018. The study population divided into four groups according quartile distribution (Q1: <2.20, Q2: 2.20 <2.97, Q3: 2.97 <4.04, Q4: ≥4.04). Multivariable Cox models employed explore associations evaluated.During median follow-up 35.5 months (interquartile range, 20.9-57.2 months), 800 died, including 416 deaths from CVD. Restricted cubic splines showed non-linear relationship adverse clinical outcomes. risks gradually increased across quartiles (log-rank, p < 0.001). After adjusting for potential confounders, highest (Q4) significantly elevated hazard ratio (HR) both (HR 1.54 [95% confidence interval (CI), 1.21-1.96]) risk 1.78 CI, 1.26-2.52]), compared lowest (Q1).AI independently associated with PD, suggesting that might be useful marker.