Outcome analysis of major cardiac operations in low weight neonates

• DOI: 10.1016/j.athoracsur.2003.12.066
• Publication Date: 2004-06-29T08:32:30Z
• Authors: Thierry Bové; Katrien François; Katya De Groote; Bert Suys; Daniel De Wolf; Hendrik Verhaaren; Dirk Matthys; Annelies Moerman; Jan Poelaert; Piet Vanhaesebroeck; Guido Van Nooten
• Keywords: Heart Defects, Congenital; Male; Reoperation; Cardiopulmonary Bypass; Critical Illness; Palliative Care; Infant, Newborn; Gestational Age; Infant, Low Birth Weight; 3. Good health; 03 medical and health sciences; Postoperative Complications; Treatment Outcome; 0302 clinical medicine; Risk Factors; Intellectual Disability; Birth Weight; Humans; Female; Hospital Mortality; Cardiac Surgical Procedures; Infant, Premature; Retrospective Studies

From June 1995 to January 2003, 49 consecutive neonates of less than 2,500 g underwent early surgery for congenital heart disease. A retrospective analysis was performed to evaluate the early to medium term outcome.Major cardiac surgery for congenital heart defects included a complete correction in 31 patients (group I) and a palliative procedure in 18 patients (group II). Mean age at operation was 15.2 days (1 day-90 days) and mean weight was 2,190 g (1,300 g-2,500 g). Twenty-four children (49%) were born prematurely. All neonates were critically ill and 47% were already ventilated preoperatively. Heart defects included mainly ventricular septal defect (10), tetralogy of Fallot complexes (8), aortic coarctation (8), transposition complexes (7), single ventricle anomalies (4), pulmonary atresia with intact septum (4), interrupted aortic arch (3), totally anomalous pulmonary venous return (3), and common atrioventricular septal defect (2).Overall surgical mortality was 18%: 4 neonates died after definitive repair and 5 after palliation; representing, respectively, 13% and 28% of each group. Postoperative morbidity occurred in half of the patients (53%). Age, weight, prematurity, type of first surgical procedure, and use of cardiopulmonary bypass did not influence the early outcome. After a mean follow-up of 2.82 years (2 months to 6 years), survival was 87% in the correction group and 54% in the palliation group. All children were in NYHA class I-II. Freedom from reintervention at 18 months was 68% after correction versus 8% after palliation.Cardiac surgery for congenital malformations in critically ill, low weight neonates can be achieved with acceptable mortality, at the cost of an increased morbidity. Early outcome seems independent of age, weight, prematurity, use of extracorporeal perfusion, and type of first intervention. Moreover, primary correction appears to result in an early survival benefit, remaining constant over time.