Changes in treatment of intracranial aneurysms during the last decade in a large European neurovascular center

• DOI: 10.1016/j.bas.2024.103813
• Publication Date: 2024-10-12T19:54:42Z
• Authors: Francesco Calvanese; Anna Maria Auricchio; Anni Pohjola; Ahmad Hafez; Ville Nurminen; Miikka Korja; Jussi Numminen; Martin Lehecka; Rahul Raj; Mika Niemelä
• Keywords: Epidemiology; Endovascular Procedures; Surgery, anesthesiology, intensive care, radiology; Intracranial Aneurysm; Aneurysm, Ruptured; Intracranial aneurysm; Embolization, Therapeutic; Neurology and psychiatry; 03 medical and health sciences; Treatment Outcome; 0302 clinical medicine; Humans; Endovascular treatment; Subarachnoid hemorrhage; Original Article; Surgical clipping; Retrospective Studies

Abstract Objective Treatment modality for ruptured and unruptured intracranial aneurysms has shifted during the last two decades from microsurgical treatment towards endovascular treatment. We present how this transition happened in a large European neurovascular center. Methods We conducted a retrospective observational study consecutive patients treated for an unruptured or ruptured intracranial aneurysm at Helsinki University Hospital during 2012–2022. We used Poisson regression analysis to report age-adjusted treatment trends by aneurysm location and rupture status. Results A total of 2491 patients with intracranial aneurysms were treated (44% ruptured, 56% unruptured): 1421 (57%) surgically and 1070 (43%) endovascularly. A general trend towards fewer treated aneurysms was noted. The proportion of patients treated surgically decreased from 90% in 2012 to 20% in 2022. The age-adjusted decrease of surgical versus endovascular treatment was 6.9%/year for all aneurysms, 6.8% for ruptured aneurysms, and 6.8% for unruptured aneurysms. The decrease of surgical treatment was most evident in unruptured vertebrobasilar aneurysms (10.8%/year), unruptured communicating artery aneurysms (10.1%/year), ruptured communicating artery aneurysms (10.0%/year), and ruptured internal carotid aneurysms (9.0%/year). There was no change in treatment modality for middle cerebral artery aneurysms, of which 85% were still surgically treated in 2022. A trend towards an increasing size for treated ruptured aneurysms was found (p = 0.033). Conclusion A significant shift of the treatment modality from surgical to endovascular treatment occurred for all aneurysm locations except for middle cerebral artery aneurysms. Whether this shift has affected long-term safety and patient outcomes should be assessed in the future.