Associations between plasma inflammatory markers and psychotic disorder, depressive disorder and generalised anxiety disorder in early adulthood: A nested case-control study

• DOI: 10.1016/j.bbi.2023.03.025
• Publication Date: 2023-03-31T07:42:49Z
• Authors: David Mongan; Subash Raj Susai; Melanie Föcking; Jonah F. Byrne; Stan Zammit; Mary Cannon; David R. Cotter
• Keywords: SuPAR

Low-grade inflammation may occur in association with several mental disorders of early adulthood, though associations markers chronic such as soluble urokinase plasminogen activator receptor (suPAR) are less well-established. We aimed to examine between acute and inflammatory disorders, well psychiatric co-morbidity, young adults aged 24 years the Avon Longitudinal Study Parents Children.Included were 781 participants (of 4019 who attended at age years) completed assessments provided plasma samples. Of these, 377 met criteria for psychotic disorder, depressive disorder or generalised anxiety 404 did not. Plasma concentrations IFN-γ, IL-6, IL-8, IL-10, TNF-α, CRP, sVCAM1, sICAM1, suPAR alpha-2-macroglobulin measured using immunoassays. Logistic regression compared standardised marker levels cases controls. Negative binomial evaluated co-morbidity (number disorders). Models adjusted sex, body mass index, cigarette smoking, cannabis use employment status, then additionally childhood trauma.For there was evidence IL-6 (odds ratio[OR] 1.68, 95 %CI 1.20-2.34) (OR 1.74, 1.17-2.58). There weaker an 1.31, 1.05-1.62). little disorder. weak (β 0.10, 0.01-0.19). additional confounding by trauma.There that 24-year-olds had raised These findings have implications regarding role adulthood.