Anti-inflammatory effects of hydroxycinnamic acid derivatives

• DOI: 10.1016/j.bbrc.2007.04.178
• Publication Date: 2007-05-08T13:33:38Z
• Authors: Reiko Nagasaka; Chatchawan Chotim...; Islam Md. Shafiqul; Masatoshi Hori; Hiroshi Ozaki; Hideki Ushio
• Keywords: Hydroxycinnamic acid

NF-kappaB family of transcription factors are involved in numerous cellular processes, including differentiation, proliferation, and inflammation. It was reported that hydroxycinnamic acid derivatives (HADs) are inhibitors of NF-kappaB activation. Rice bran oil contains a lot of phytosteryl ferulates, one of HADs. We have investigated effects of phytosteryl ferulates on NF-kappaB activation in macrophage. Cycloartenyl ferulate (CAF), one of phytosteryl ferulates, significantly reduced lipopolysaccharide (LPS)-induced NO production and mRNA expression of inducible NO synthase and cyclooxygenese-2 but upregulated SOD activity. Electrophoresis mobility shift assay revealed that CAF inhibited DNA-binding of NF-kappaB. CAF and phytosteryl ferulates probably have potentially anti-inflammatory properties.