Gaining insights into relevance across cancers based on mutation features of TP53 gene

• DOI: 10.1016/j.bbrep.2021.101165
• Publication Date: 2021-11-03T07:20:51Z
• Authors: Yue Mei; Dong Liang; Tengjiao Wang; Dong Yu
• Keywords: Gene signature

The tumor suppressor gene TP53, one of the most frequently mutated genes, is recognized as guardian genome and can provide a significant barrier to neoplastic transformation progression. Traditional theory believes that TP53 mutations are equal among cancer types. However, date, no study has explored mutation profile from holistic systematic standpoint discovery its relevance feature with cancers. Mutation signature, an unbiased approach identify mutational processes, be potent indicator for exploring mutation-driven occurrence In this research, several features such hotspots, mutability signature somatic derived 18 types tissues cBioPortal were analyzed manifested organizational preference signatures found in almost all Signature 6 related mismatch repair deficiency, 1 reflects natural decomposition 5-methylcytosine into thymine associated aging. Meanwhile, displayed tissue-selective. Mutations enriched bladder, skin, lung APOBEC activity (Signature 2 13), alkylating agents 11), tobacco smoke 4), respectively. Moreover, 4 29 smoking or chewing lung, sarcoma, esophageal, head neck may their history. addition, digestive cancers, including colorectal, stomach, pancreatic esophageal showed high correlation context profiles. Our suggests tissue-selective processes would reflect tissue-specific enrichment provides new perspective understand diverse diseases based on spectrum mutations.