Diazepam effects on local cortical neural activity during sleep in mice

• DOI: 10.1016/j.bcp.2021.114515
• Publication Date: 2021-03-10T23:08:08Z
• Authors: Laura E. McKillop; Simon P. Fisher; Linus Milinski; Lukas B. Krone; Vladyslav V. Vyaz...
• Keywords: Local field potential; Sleep

GABA-ergic neurotransmission plays a key role in sleep regulatory mechanisms and brain oscillations during sleep. Benzodiazepines such as diazepam are known to induce sedation promote sleep, however, EEG spectral power slow frequencies is typically reduced after the administration of benzodiazepines or similar compounds. waves arise from synchronous alternation between periods cortical network activity (ON) silence (OFF), represent sensitive marker preceding sleep-wake history. Yet it remains unclear how act on neural To address this, we obtained chronic recordings local field potentials multiunit (MUA) deep layers primary motor cortex freely behaving mice injection. We found that amplitude individual LFP was significantly injection accompanied by lower incidence duration corresponding neuronal OFF periods. Further investigation suggested this due disruption synchronisation neurons. Our data suggest state global synchrony can be dissociated, induced qualitatively different spontaneous physiological