Virus-inspired surface-nanoengineered antimicrobial liposome: A potential system to simultaneously achieve high activity and selectivity

• DOI: 10.1016/j.bioactmat.2021.02.038
• Publication Date: 2021-03-12T12:01:26Z
• Authors: Yin Shi; Xiaoqian Feng; Liming Lin; Jing Wang; Jiaying Chi; Biyuan Wu; Guilin Zhou; Feiyuan Yu; Qian Xu; Daojun Liu; Guilan Quan; Chao Lu; Xin Pan; Jianfeng Cai; Chuanbin Wu
• Keywords: Lipopeptide; Rational design

Enveloped viruses such as SARS-CoV-2 frequently have a highly infectious nature and are considered effective natural delivery systems exhibiting high efficiency specificity. Since simultaneously enhancing the activity selectivity of lipopeptides is seemingly unsolvable problem for conventional chemistry pharmaceutical approaches, we present biomimetic strategy to construct lipopeptide-based mimics viral architectures infections enhance their antimicrobial efficacy while avoiding side effects. Herein, surface-nanoengineered liposome (SNAL) developed with morphological features enveloped viruses, including moderate size range, lipid-based membrane structure, lipopeptide-enriched bilayer surface. The SNAL possesses virus-like infection bacterial cells, which can mediate high-efficiency high-selectivity bacteria binding, rapidly attack invade via plasma fusion pathway, induce local "burst" release lipopeptide produce irreversible damage cell membrane. Remarkably, against multiple pathogens low minimum inhibitory concentrations (1.6–6.3 μg mL−1), bactericidal >99% within 2 h, >10-fold enhanced over free lipopeptide, 99.8% reduction in skin MRSA load after single treatment, negligible toxicity. This bioinspired design has significant potential therapeutic may create new opportunities designing next-generation antimicrobials.