Magnetic lipid nanovehicles synergize the controlled thermal release of chemotherapeutics with magnetic ablation while enabling non-invasive monitoring by MRI for melanoma theranostics

• DOI: 10.1016/j.bioactmat.2021.06.009
• Publication Date: 2021-06-17T10:50:23Z
• Authors: Lorena García-Hevia; Íñigo Casafont; Jessica Oliveira; Nuria Terán; Mónica L. Fanarraga; Juan Gallo; Manuel Bañobre-López
• Keywords: 0301 basic medicine; 03 medical and health sciences; Theranosis; Magnetic resonance imaging; QH301-705.5; TA401-492; Magnetic hyperthermia; Biology (General); Materials of engineering and construction. Mechanics of materials; Melanoma; Article; Drug delivery systems

Nowadays, a number of promising strategies are being developed that aim at combining diagnostic and therapeutic capabilities into clinically effective formulations. Thus, the combination modified release provided by an organic encapsulation intrinsic physico-chemical properties from inorganic counterpart opens new perspectives in biomedical applications. Herein, biocompatible magnetic lipid nanocomposite vehicle was through efficient, green simple method to simultaneously incorporate nanoparticles anticancer drug (doxorubicin) natural nano-matrix. The theranostic performance final formulation validated vitro vivo, melanoma tumors. systemic administration proposed hybrid carrier enhanced anti-tumoral activity synergistic hyperthermia effects antimitotic therapy, together with MRI reporting capability. application alternating field found play dual role, (i) acting as extra layer control (remote, on-demand) over chemotherapy (ii) inducing local thermal ablation tumor cells. This thermotherapy establishes platform for treatment solid malignant tumors under lower dosing schemes, which may realize goal reduced toxicity efficacy.