A Mg2+/polydopamine composite hydrogel for the acceleration of infected wound healing

• DOI: 10.1016/j.bioactmat.2021.11.036
• Publication Date: 2021-12-20T22:21:18Z
• Authors: Zhaoyuan Guo; Zhuangzhuang Zhang; Nan Zhang; Wenxia Gao; Jing Li; Yuji Pu; Bin He; Jing Xie
• Keywords: Polyacrylamide

Bacterial infection is a vital factor to delay the wound healing process. The antibiotics abuse leads drug resistance of some pathogenic bacteria. Non-antibiotic-dependent multifunctional biomaterials with accelerated performance are urgently desired. Herein, we reported composite antibacterial hydrogel PDA-PAM/Mg2+ that shows excellent self-healing and tissue adhesive property, photothermal functions for accelerating healing. gel was composed polyacrylamide (PAM), polydopamine (PDA), magnesium (Mg2+) prepared via two-step procedure: an alkali-induced dopamine pre-polymerization followed radical polymerization adhesiveness Mg2+-synergized activity, inducing survival rate 5.29% S. aureus 7.06% E. coli after near infrared light irradiation. further demonstrated efficient bacteria inhibition, enhanced collagen deposition in full-thickness skin defect rat model. Together, presents dressing adhesion, healing, functions.