Brain-targeting, acid-responsive antioxidant nanoparticles for stroke treatment and drug delivery

• DOI: 10.1016/j.bioactmat.2022.02.033
• Publication Date: 2022-03-07T22:44:02Z
• Authors: Shenqi Zhang; Bin Peng; Zeming Chen; Jiang Yu; Gang Deng; Youmei Bao; Chao Ma; Fengyi Du; Wendy C. Sheu; W. Taylor Kimberly; J. Marc Simard; Daniel Coman; Qianxue Chen; Fahmeed Hyder; Jiangbing Zhou; Kevin N. Sheth
• Keywords: Betulinic acid; Stroke; Targeted drug delivery

Stroke is the leading cause of death and disability. Currently, there no effective pharmacological treatment for this disease, which can be partially attributed to inability efficiently deliver therapeutics brain. Here we report development natural compound-derived nanoparticles (NPs), function both as a potent therapeutic agent stroke an efficient carrier drug delivery ischemic First, screened collection nanomaterials identified betulinic acid (BA) one most antioxidants treatment. Next, engineered BA NPs preferential release in acidic tissue through chemically converting amine (BAM) targeted surface conjugation AMD3100, CXCR4 antagonist. The resulting AMD3100-conjugated BAM NPs, or A-BAM were then assessed NA1, neuroprotective peptide. We show that intravenous administration effectively improved recovery from its efficacy was further enhanced when NA1 encapsulated. Due their multifunctionality significant efficacy, anticipate have potential translated improve stroke.