Double-network hydrogel enhanced by SS31-loaded mesoporous polydopamine nanoparticles: Symphonic collaboration of near-infrared photothermal antibacterial effect and mitochondrial maintenance for full-thickness wound healing in diabetes mellitus

• DOI: 10.1016/j.bioactmat.2023.04.004
• Publication Date: 2023-04-21T18:06:41Z
• Authors: Qing-Song Deng; Yuan Gao; Bi-Yu Rui; Xu-Ran Li; Po-Lin Liu; Zi-Yin Han; Zhan-Ying Wei; Chang-Ru Zhang; Fei Wang; Helen Dawes; Tong-He Zhu; Shi-Cong Tao; Shang-Chun Guo
• Keywords: QH301-705.5; Diabetic wound healing; TA401-492; Mesoporous polydopamine nanoparticles (MPDA NPs); Biology (General); Photothermal antibacterial; Materials of engineering and construction. Mechanics of materials; Mitochondrial function maintenance; Article; 3. Good health; SS31

Diabetic wound healing has become a serious healthcare challenge. The high-glucose environment leads to persistent bacterial infection and mitochondrial dysfunction, resulting in chronic inflammation, abnormal vascular function, tissue necrosis. To solve these issues, we developed double-network hydrogel, constructed with pluronic F127 diacrylate (F127DA) hyaluronic acid methacrylate (HAMA), enhanced by SS31-loaded mesoporous polydopamine nanoparticles (MPDA NPs). As components, SS31, mitochondria-targeted peptide, maintains reduces reactive oxygen species (ROS) thus regulates macrophage polarization, as well promoting cell proliferation migration, while MPDA NPs not only scavenge ROS exert an anti-bacterial effect photothermal treatment under near-infrared light irradiation, but also control release of SS31 response ROS. This F127DA/HAMA-MPDA@SS31 (FH-M@S) hydrogel characteristics adhesion, superior biocompatibility mechanical properties which can adapt irregular wounds at different body sites provide sustained MPDA@SS31 (M@S) NPs. In addition, diabetic rat full thickness skin defect model, the FH-M@S promoted M2 collagen deposition, neovascularization healing. Therefore, exhibits promising therapeutic potential for regeneration.