Glucose-responsive, antioxidative HA-PBA-FA/EN106 hydrogel enhanced diabetic wound healing through modulation of FEM1b-FNIP1 axis and promoting angiogenesis

• DOI: 10.1016/j.bioactmat.2023.07.006
• Publication Date: 2023-07-22T10:20:22Z
• Authors: Wenqian Zhang; Kangkang Zha; Yuan Xiong; Weixian Hu; Lang Chen; Ze Lin; Chenyan Yu; Wu Zhou; Faqi Cao; Hankun Hu; Bobin Mi; Guohui Liu
• Keywords: Phenylboronic acid

The diabetic wounds remain to be unsettled clinically, with chronic characterized by drug-resistant bacterial infections, compromised angiogenesis and oxidative damage the microenvironment. To ameliorate stress applying antioxidant treatment in wound site, we explore function of folliculin-interacting protein 1 (FNIP1), a mitochondrial gatekeeper works alter morphology, reduce phosphorylation protect cells from unwarranted ROS accumulation. And our vitro experiments showed effects FNIP1 ameliorating rescued impaired HUVECs high glucose environment. realize drug delivery local regulation sites, novel designed glucose-responsive HA-PBA-FA/EN106 hydrogel is introduced for improving healing. Due dynamic phenylboronate ester structure phenylboronic acid group between hyaluronic (HA) (PBA), able release drugs. Fulvic (FA) added hydrogel, which not only severs as crosslinking agent but also provides antibacterial anti-inflammatory abilities. Moreover, FEM1b-FNIP1 axis inhibitor EN106 ameliorated stimulated through regulation. These vivo results demonstrated that accelerated repair use may provide promising strategy repair.