Experimental modulation and computational model of nano-hydrophobicity

• DOI: 10.1016/j.biomaterials.2015.02.043
• Publication Date: 2015-02-28T12:31:37Z
• Authors: Shuhuan Li; Shumei Zhai; Yin Liu; Hongyu Zhou; Jinmei Wu; Qing Jiao; Bin Zhang; Hao Zhu; Bing Yan
• Keywords: Modulation (music)

We demonstrate that nano-hydrophobicity, which governs the biological aggressiveness of nanoparticles, is determined by the outermost regions of surface ligands. We have also successfully modulated nano-hydrophobicity using systematic surface ligand modifications and built the first computational model of nano-hydrophobicity.