Novel BODIPY-based nano-biomaterials with enhanced D-A-D structure for NIR-triggered photodynamic and photothermal therapy

• DOI: 10.1016/j.bioorg.2024.107494
• Publication Date: 2024-05-23T23:41:25Z
• Authors: Gang Chen; Mengmeng Xiong; Chen Jiang; Yimei Zhao; Li Chen; Yunlong Ju; Jun Jiang; Zekun Xu; Jie Pan; Xiang Li; Kai Wang
• Keywords: Boron Compounds; Mice, Inbred BALB C; Photosensitizing Agents; Molecular Structure; Dose-Response Relationship, Drug; Photothermal Therapy; Infrared Rays; Cell Survival; Antineoplastic Agents; Biocompatible Materials; Neoplasms, Experimental; Mice; Structure-Activity Relationship; Photochemotherapy; Humans; Animals; Nanoparticles; Drug Screening Assays, Antitumor; Cell Proliferation

Near-infrared (NIR) responsive nanoparticles are an important platform for multimodal phototherapy. Importantly, the simultaneous NIR-triggered photodynamic (PDT) and photothermal (PTT) therapy is a powerful approach to increase the antitumor efficiency of phototherapic nanoparticles due to the synergistic effect. Herein, a boron dipyrromethene (BODIPY)-based amphiphilic dye with enhanced electron donor-acceptor-donor (D-A-D) structure (BDP-AP) was designed and synthesized, which could self-assemble into stable nanoparticles (BDP-AP NPs) for the synergistic NIR-triggered PDT/PTT therapy. BDP-AP NPs synchronously generated singlet oxygen (1O2) and achieved preeminent photothermal conversion efficiency (61.42%). The in vitro and in vivo experiments showed that BDP-AP NPs possessed negligible dark cytotoxicity and infusive anticancer performance. BDP-AP NPs provide valuable guidance for the construction of PDT/PTT-synergistic NIR nanoagents to improve the efficiency of photoinduced cancer therapy in the future.