Arborvitae ( Thuja plicata ) essential oil significantly inhibited critical inflammation- and tissue remodeling-related proteins and genes in human dermal fibroblasts

• DOI: 10.1016/j.biopen.2017.02.003
• Publication Date: 2017-02-21T02:00:16Z
• Authors: Xuesheng Han; Tory L. Parker
• Keywords: 0301 basic medicine; 03 medical and health sciences; Short communication; 3. Good health

Arborvitae (Thuja plicata) essential oil (AEO) is becoming increasingly popular in skincare, although its biological activity human skin cells has not been investigated. Therefore, we sought to study AEO's effect on 17 important protein biomarkers that are closely related inflammation and tissue remodeling by using a pre-inflamed dermal fibroblast culture model. AEO significantly inhibited the expression of vascular cell adhesion molecule 1 (VCAM-1), intracellular (ICAM-1), interferon gamma-induced 10 (IP-10), interferon-inducible T-cell chemoattractant (I-TAC), monokine induced gamma (MIG), macrophage colony-stimulating factor (M-CSF). It also showed significant antiproliferative robustly collagen-I, collagen-III, plasminogen activator inhibitor-1 (PAI-1), inhibitor metalloproteinase 2 (TIMP-1 TIMP-2). The inhibitory increased production these suggests it anti-inflammatory property. We then studied genome-wide 21,224 genes same culture. diversely modulated global gene expression. Ingenuity pathway analysis (IPA) affected numerous critical signaling pathways involved inflammatory processes. findings this provide first evidence beneficial action cells.