The potential antioxidant bioactivity of date palm fruit against gentamicin-mediated hepato-renal injury in male albino rats

• DOI: 10.1016/j.biopha.2021.112154
• Publication Date: 2021-09-28T12:05:15Z
• Authors: Ahmed Abdeen; Amira Samir; Ashraf Elkomy; Mohamed Aboubaker; Ola A. Habotta; Ahmed Gaber; Walaa F. Alsanie; Omnia Abdullah; Heba A. Elnoury; Bodour Baioumy; Samah F. Ibrahim; Afaf Abdelkader
• Keywords: Malondialdehyde

Gentamicin (GM) is a commonly prescribed antimicrobial drug used for treatment of infections but associated hepatic and renal complications restrict its efficacy. Overproduction free radicals inflammation are involved in GM-induced hepato-renal damage. Date palm renowned to have antioxidant anti-inflammatory bioactive composites. In this context, the current research was purposed assess ameliorative influence date extract (DE) supplementation against injury. Gas chromatography-mass spectrometry (GC–MS) detect constitutes DE. The protective action high low doses DE assessed alongside GM remediation (80 mg/kg) rats. evoked significant alterations liver kidney function biomarkers (aminotransferases, albumin, creatinine, blood urea). Furthermore, notable elevations malondialdehyde (MDA) level increment expression inducible nitric oxide synthase (iNOS) along with reduction catalase (CAT) activity were observed both organs after treatment. Oxidative stress main modulatory mechanism toxicity. However, could mitigate GM-inflicted damage, dose-response pattern, due content phenolics flavonoids.