Human urinary kininogenase reduces the endothelial injury by inhibiting Pyk2/MCU pathway

• DOI: 10.1016/j.biopha.2021.112165
• Publication Date: 2021-09-17T07:03:06Z
• Authors: Xiaoli Yang; Zhongzhong Li; Yingzhen Zhang; Kailin Bu; Jing Tian; Junzhao Cui; Jin Qin; Ruijie Zhao; Shuxia Liu; Guojun Tan; Xiaoyun Liu
• Keywords: Male; 0301 basic medicine; Receptor, Bradykinin B2; Carotid Artery, Common; Apoptosis; Hydrogen Peroxide; Rats; Rats, Sprague-Dawley; Disease Models, Animal; 03 medical and health sciences; Focal Adhesion Kinase 2; Neointima; Human Umbilical Vein Endothelial Cells; Animals; Humans; Kallikreins; Calcium Channels; Carotid Artery Injuries; Cells, Cultured; Signal Transduction

The injury of endothelial cells is one the initiating factors in restenosis after endovascular treatment. Human urinary kallidinogenase (HUK) a tissue kallikrein which used for ischemia-reperfusion Studies have shown that HUK may be potential therapeutic agent to prevent stenosis vascular injury, however, precise mechanisms not been fully established. This study investigate whether can protect balloon or H