Lack of berberine effect on bone mechanical properties in rats with experimentally induced diabetes

• DOI: 10.1016/j.biopha.2021.112562
• Publication Date: 2021-12-29T11:09:36Z
• Authors: Piotr Londzin; Sonia Kocik; Ewa Kisiel-Nawrot; Aleksandra Janas; Anna Skoczyńska; Zora Krivošíková; Kornélia Štefíková; Martin Gajdoš; Urszula Cegieła; Joanna Folwarczna
• Keywords: Cancellous bone; Bone remodeling

Multidirectional health-promoting activities of some plant-derived substances make them candidates for drugs used in diabetes and its complications such as osteoporosis. Berberine is a compound which both antidiabetic antiosteoporotic effects have been documented. The aim the study was to investigate berberine on skeletal disorders induced by experimental type 1 rats. experiments were performed 3-month-old female rats, divided into three groups: I - healthy control II diabetic III rats receiving berberine. Diabetes single streptozotocin injection. administration (50 mg/kg/day p.o.) started two weeks later lasted four weeks. Serum bone turnover markers other biochemical parameters, mass mineralization, histomorphometric parameters mechanical properties studied. strong turnover, microarchitecture, strength cancellous bone. counteracted effect formation marker (osteocalcin) concentration, growth plate, but did not improve mineralization lack quality does support use prevention diabetes-induced damage.