Spiraea prunifolia leaves extract inhibits adipogenesis and lipogenesis by promoting β-oxidation in high fat diet-induced obese mice

• DOI: 10.1016/j.biopha.2022.112889
• Publication Date: 2022-03-31T13:14:01Z
• Authors: Ju-Hyoung Park; Eun-Kyung Ahn; Hye-Jin Ko; Min Hee Hwang; Young-Rak Cho; Dong-Ryung Lee; Bong-Keun Choi; Dong-Wan Seo; Joa Sub Oh
• Keywords: Lipogenesis

Spiraea prunifolia has been used in Korean traditional medicine to treat malaria, fever, and emetic conditions. Previous investigation reported that several parts of show various functional effects. However, the effect leaves extract (SPE) on anti-obesity remains unclear. Therefore, we a high-fat diet (HFD)-induced obese mouse model this study investigate effects SPE adipogenesis, lipogenesis, β-oxidation. Oral administration HFD-induced mice considerably reduced body weight, serum levels such as total cholesterol, triglyceride, high-density lipoprotein low-density adipose tissue adipocyte cell size. Moreover, significantly decreased protein expression adipogenesis lipogenesis related genes CCAAT/enhancer binding α, peroxisome proliferator-activated receptor γ, 2, acetyl-CoA carboxylase, fatty acid synthase epididymal tissues. treatment induced carnitine palmitoyl transferase-1, which might have promoted phosphorylated AMP-activated kinase-medicated The present reveals an anti-adipogenic, anti-lipogenic, β-oxidation vivo represents kinase signaling targets for SPE.