Changes in the immune response against SARS-CoV-2 in individuals with severe COVID-19 treated with high dose of vitamin D

• DOI: 10.1016/j.biopha.2022.112965
• Publication Date: 2022-04-14T07:13:33Z
• Authors: Montserrat Torres; Guiomar Casado; Lorena Vigón; Sara Rodríguez-Mora; Elena Mateos; Fernando Ramos-Ma...; Daniel López-Wolf; José Sanz-Moreno; Pablo Ryan-Murua; María Luisa Taboa...; María Rosa López-...; Miguel Cervero; Mayte Coiras; David Alonso-Menchén; Sandra Arévalo Ca...; Cristina Avila Ca...; José Antonio Barb...; Natalia Blanca López; Irene Cañamares O...; Gema Carrillo Blanco; Almudena Cascajer...; María Teresa Chic...; Ana Corrochano Ga...; Sara Corredera Ga...; Victor Díez Viñas; Marta Gómez-Alvar...; Claudia Patricia ...; Yanira Fernández ...; Eva Fonseca Aizpuri; Concepción García...; Javier García-Pérez; Cristina Helguera...; Francisco José Hi...; Amparo Lucena Cam...; Mariano Matarranz...; Oriol Martín Sagarra; Emilio José Martí...; José Javier Martí...; María Novella-Mena; Virginia Pardo Gu...; María Luisa Pinil...; Fr`ancisca Ramíre...; Daniel Renuncio G...; María Angeles Rod...; Almudena Roger Re...; Lourdes Sampablo ...; José Sanz Moreno; Rafael Torres Perea; Jorge Valencia La...; María Velasco Arr...; Ana Villanueva Fe...
• Keywords: Vitamin D supplementation; Respiratory Distress Syndrome; 0303 health sciences; Immune cytotoxic response; SARS-CoV-2; Immunity; COVID-19; Vitamins; Article; COVID-19 Drug Treatment; 3. Good health; 03 medical and health sciences; Dietary Supplements; Humans; Single-Blind Method; Prospective Studies; Vitamin D; Cholecalciferol

Main cause of severe illness and death in COVID-19 patients appears to be an excessive but ineffectual inflammatory immune response that may acute respiratory distress syndrome (ARDS). Vitamin D favour anti-inflammatory environment improve cytotoxic against some infectious diseases. A multicenter, single-blind, prospective, randomized clinical trial was approved with pneumonia levels 25-hydroxyvitamin (25(OH)D) 14.8 ng/ml (SD: 6.18) test antiviral efficacy, tolerance safety 10,000 IU/day cholecalciferol (vitamin