The Chinese herbal medicine Fufang Zhenzhu Tiaozhi ameliorates diabetic cardiomyopathy by regulating cardiac abnormal lipid metabolism and mitochondrial dynamics in diabetic mice

• DOI: 10.1016/j.biopha.2023.114919
• Publication Date: 2023-06-09T10:14:25Z
• Authors: Meiling Yan; Suping Liu; Wenru Zeng; Qiaoling Guo; Yu Mei; Xiaoqi Shao; Liyan Su; Zhou Liu; Yue Zhang; Lexun Wang; Hongtao Diao; Xianglu Rong; Jiao Guo
• Keywords: Diabetic Cardiomyopathy; CD36

Diabetic cardiomyopathy (DCM) is an important complication leading to the death of patients with diabetes, but there no effective strategy for clinical treatments. Fufang Zhenzhu Tiaozhi (FTZ) a patent medicine that traditional Chinese compound preparation comprehensive effects prevention and treatment glycolipid metabolic diseases under guidance "modulating liver, starting pivot cleaning turbidity". FTZ was proposed by Professor Guo Jiao used hyperlipidemia. This study designed explore regulatory mechanisms on heart lipid metabolism dysfunction mitochondrial dynamics disorder in mice DCM, it provides theoretical basis myocardial protective effect diabetes. In this study, we demonstrated protected function DCM downregulated overexpression free fatty acids (FFAs) uptake-related proteins cluster differentiation 36 (CD36), acid binding protein 3 (FABP3) carnitine palmitoyl transferase 1 (CPT1). Moreover, showed inhibiting fission promoting fusion. We also identified vitro could restore metabolism-related proteins, dynamics-related energy PA-treated cardiomyocytes. Our indicated improves cardiac diabetic attenuating increase fasting blood glucose levels, decrease body weight, alleviating disordered metabolism, restoring apoptosis mouse hearts.