A pan-PPAR agonist E17241 ameliorates hyperglycemia and diabetic dyslipidemia in KKAy mice via up-regulating ABCA1 in islet, liver, and white adipose tissue

• DOI: 10.1016/j.biopha.2024.116220
• Publication Date: 2024-02-02T13:12:22Z
• Authors: Ren Sheng; Yining Li; Yexiang Wu; Chang Liu; Weizhi Wang; Xiaowan Han; Yinghong Li; Lijuan Lei; Xinhai Jiang; Yuyan Zhang; Yuhao Zhang; Shunwang Li; Bin Hong; Chao Liu; Yanni Xu; Shuyi Si
• Keywords: Rosiglitazone; Fenofibrate

Type 2 diabetes mellitus (T2DM) is a common chronic metabolic disease. Peroxisome proliferator-activated receptors (PPARs) play crucial roles in regulating glucolipid metabolism. Previous studies showed that E17241 could ameliorate atherosclerosis and lower fasting blood glucose levels ApoE