The effect of lipid metabolism on cuproptosis-inducing cancer therapy

• DOI: 10.1016/j.biopha.2024.116247
• Publication Date: 2024-02-07T04:08:56Z
• Authors: Yue Zhong; Wei Zeng; Yongbo Chen; Xiuzhi Zhu
• Keywords: 0303 health sciences; 03 medical and health sciences

Cuproptosis provides a new therapeutic strategy for cancer treatment and is thought to have broad clinical application prospects. Nevertheless, some oncological trials yet demonstrate favorable outcomes, highlighting the need further research into molecular mechanisms underlying cuproptosis in tumors. primarily hinges on intracellular accumulation of copper, with lipid metabolism exerting profound influence its course. The interaction between copper closely related cuproptosis. Copper imbalance can affect mitochondrial respiration changes, while promote uptake absorption, inhibit induced by copper. Anomalies disrupt homeostasis within cells, potentially triggering regulates occurrence, development, metastasis, chemotherapy drug resistance, tumor immunity cancer. promising target treatment. However, other factors should be taken consideration. This review brief overview characteristics analyses potential strategies applying