Unlocking the potential of flavonoids: Natural solutions in the fight against colon cancer

• DOI: 10.1016/j.biopha.2024.116827
• Publication Date: 2024-06-10T01:45:39Z
• Authors: Poppy Anjelisa Za...; Yogi Simanjuntak; Evamarie Hey-Hawkins; Muhammad Fauzan L...; Ade Sri Rohani; Moon Nyeo Park; Bonglee Kim; Rony Abdi Syahputra
• Keywords: Flavonoids; 0303 health sciences; 03 medical and health sciences; Colonic Neoplasms; Humans; Animals; Gastrointestinal Microbiome

Colorectal cancer (CRC) is a major cause of cancer-related deaths worldwide, underscoring the importance understanding diverse molecular and genetic underpinnings CRC to improve its diagnosis, prognosis, treatment. This review delves into adenoma-carcinoma-metastasis model, emphasizing "APC-KRAS-TP53" signature events in development. categorized four consensus subtypes, each characterized by unique alterations responses therapy, illustrating complexity heterogeneity. Furthermore, we explore role chronic inflammation gut microbiome progression, potential targeting these factors for prevention discusses impact dietary carcinogens lifestyle critical early detection improving outcomes, also examines conventional chemotherapy options associated challenges. There significant focus on therapeutic flavonoids management, discussing various types flavonoids, their sources, mechanisms action, including antioxidant properties, modulation cell signaling pathways, effects cycle apoptosis. article presents evidence synergistic with therapies modulating immune response, thereby offering new avenues We conclude multidisciplinary approach research treatment, incorporating insights from genetic, molecular, factors. Further needed preventive natural compounds, such as CRC, need personalized targeted treatment strategies.