Osteophyte size and location on hip DXA scans are associated with hip pain: Findings from a cross sectional study in UK Biobank

• DOI: 10.1016/j.bone.2021.116146
• Publication Date: 2021-08-11T04:56:55Z
• Authors: Benjamin G. Faber; Raja Ebsim; Fiona R. Saunders; Monika Frysz; Claudia Lindner; Jennifer S. Gregory; Richard M. Aspden; Nicholas C. Harvey; George Davey Smith; Timothy Cootes; Jonathan H. Tobias
• Keywords: 610; Pain; Dual-energy x-ray absorptiometry; R Medicine; MC_UU_00011/1; Article; Osteoarthritis, Hip; 03 medical and health sciences; Absorptiometry, Photon; 0302 clinical medicine; Osteoarthritis; MR/S00405X/1; Humans; Wellcome Trust; Biological Specimen Banks; R; Osteophyte; 209233; Joint space narrowing; joint space narrowing; Medical Research Council (MRC); United Kingdom; 3. Good health; Radiography; Cross-Sectional Studies; osteophyte; MR/S021280/1; Hip pain; hip pain

It remains unclear how the different features of radiographic hip osteoarthritis (rHOA) contribute to pain. We examined relationship between rHOA, including its individual components, and pain using a novel dual-energy x-ray absorptiometry (DXA)-based method. Hip DXAs were obtained from UK Biobank. A automated method minimum joint space width (mJSW) points placed around femoral head acetabulum. Osteophyte areas at lateral acetabulum, superior inferior derived manually. Semi-quantitative measures osteophytes narrowing (JSN) combined define rHOA. Logistic regression was used examine relationships these variables pain, via questionnaires. 6807 examined. rHOA present in 353 (5.2%) individuals associated with [OR 2.42 (1.78–3.29)] hospital diagnosed OA [6.01 (2.98–12.16)]. Total osteophyte area but not mJSW mutually adjusted models [1.31 (1.23–1.39), 0.95 (0.87–1.04) respectively]. On other hand, JSN as categorical variable showed weak associations grade ≥ 1 2 [1.30 (1.06–1.60), 1.80 (1.34–2.42) Acetabular, all independently [1.13 (1.06–1.20), 1.13 (1.05–1.24), 1.10 (1.03–1.17) In this cohort, prevalent explained by 2-dimensional area, apparent mJSW. Osteophytes locations important, potentially independent, possibly reflecting contribution distinct biomechanical pathways.