Imaging-based programming of subthalamic nucleus deep brain stimulation in Parkinson's disease

• DOI: 10.1016/j.brs.2021.07.064
• Publication Date: 2021-08-02T05:32:01Z
• Authors: Josefine Waldthaler; Miriam Bopp; Nele Kühn; Bugrahan Bacara; Merle Keuler; Marko Gjorgjevski; Barbara Carl; Lars Timmermann; Christopher Nimsky; David J. Pedrosa
• Keywords: Subthalamic Nucleus; Motor symptoms

BackgroundThe need for imaging-guided optimization of Deep Brain Stimulation (DBS) parameters is increasing with recent developments sophisticated lead designs offering highly individualized, but time-consuming and complex programming.ObjectiveThe objective this study was to compare changes in motor symptoms Parkinson's Disease (PD) the corresponding volume electrostatic field (VEsF) achieved by DBS programming using GUIDE XT™, a commercially available software visualization leads within patient-specific anatomy from fusions preoperative magnetic resonance imaging (MRI) postoperative computed tomography (CT) scans, versus standard-of-care clinical programming.MethodsClinical evaluation performed identify optimal set based on effects 29 patients PD bilateral directional Subthalamic Nucleus (STN) DBS. A second program generated XT™ VEsF optimally located dorsolateral STN. Reduction (Movement Disorders Society Unified Rating Scale, MDS-UPDRS) overlap both programs were compared.ResultsClinical resulted significant reduction MDS-UPDRS scores compared off-state. Motor symptom control XT™-derived non-inferior standard programming. The two did not correlate difference programs.ConclusionsImaging-guided possible without computational background data may thus serve as starting point testing promote more efficient