Phase- targeted stimulation modulates phase-amplitude coupling in the motor cortex of the human brain

• DOI: 10.1016/j.brs.2021.11.019
• Publication Date: 2021-11-30T19:17:20Z
• Authors: Yousef Salimpour; Kelly A. Mills; Brian Y. Hwang; William S. Anderson
• Keywords: Local field potential; Brain stimulation

Phase-amplitude coupling (PAC) in which the amplitude of a faster field potential oscillation is coupled to phase slower rhythm, one most well-studied interactions between oscillations at different frequency bands. In healthy brain, PAC accompanies cognitive functions such as learning and memory, changes have been associated with neurological diseases including Parkinson's disease (PD), schizophrenia, obsessive-compulsive disorder, Alzheimer's disease, epilepsy./Hypothesis: PD, normalization motor cortex has reported context effective treatments dopamine replacement therapy deep brain stimulation (DBS), but possibility normalizing through intervention not shown humans. Phase-targeted (PDS) strong modulate levels potentially normalize it.We applied pulses triggered by specific phases beta oscillations, low that define gamma beta-gamma PAC, seven PD patients rest during DBS lead placement surgery We measured effect on modulation relative stimulation-free periods.We describe system for phase-targeted locked continuously updated slow local (in this case, band oscillations) prediction. Stimulation peak increased both after cortex, opposite (trough) reduced magnitude stimulation.These results demonstrate capacity cortical without evoking activation, could allow applications treatment disorders abnormal PD.