Restoration of functional network state towards more physiological condition as the correlate of clinical effects of pallidal deep brain stimulation in dystonia

• DOI: 10.1016/j.brs.2022.08.025
• Publication Date: 2022-09-09T17:45:09Z
• Authors: Pavel Filip; Robert Jech; Anna Fečíková; Petra Havránková; Filip Růžička; Karsten Mueller; Dušan Urgošík
• Keywords: Neuromodulation; Movement Disorders

BackgroundDeep brain stimulation of the internal globus pallidus (GPi DBS) is an invasive therapeutic modality intended to retune abnormal central nervous system patterns and relieve patient dystonic or other motor symptoms.ObjectivesThe aim presented research was determine neuroanatomical signature GPi DBS modulation its association with clinical outcome.MethodsThis open-label fixed-order study cross-sectional validation against healthy controls analysed resting-state functional MRI activity changes induced by in 18 dystonia patients heterogeneous aetiology, focusing on both global (full brain) local connectivity (local signal homogeneity).ResultsCompared switched-off state, activation led restoration subcortical (in putamina, diencephalon brainstem) towards those controls, positive direct correlation over large-scale cortico-basal ganglia-thalamo-cortical cerebellar networks improvement. Nonetheless, average, also seemed bring cortical regions farther away from state detected controls. Interestingly, outcome showed that better responders, defied this effect approached controls.ConclusionsAll all, extent these main metrics interest levels found clearly correlated improvement, indicating network more physiological condition may be a precondition for successful dystonia.